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4% on rosiglitazone in combination with maximum doses of metformin. The changes occurred primarily during the first 3?months following initiation of rosiglitazone therapy or following an increase in rosiglitazone dose. White blood cell counts also decreased slightly in adult patients treated with rosiglitazone. Healthcare professionals should consider the risk of fracture when initiating or treating female patients with type 2 diabetes mellitus with rosiglitazone. 3%, respectively) were observed for rosiglitazone maleate alone and in combination with other hypoglycemic agents.

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